MEPI Connect is a software system that supports medical schools to track and engage with their graduates. The system allows users to view and analyze graduates’ demographic and professional information. The information is obtained initially from the school registrar’s office, then from the graduates themselves, and, when possible, from human resources information systems at ministries of health and/or professional councils. The software was developed by the PEPFAR-funded Medical Education Partnership Initiative (MEPI) Physician Tracking Technical Working Group in collaboration with CapacityPlus and the MEPI Coordinating Center. This document describes resource requirements to customize and implement the system.