Human resources information systems are successful when they support policy and management decisions and when those decisions lead to better health care. However, success depends on the quality of the human resources for health data going into the system. The aim of this technical brief is to convey why data standards matter. The authors review organizational, national, and international data standards that can help ensure data quality, provide country examples, and discuss the key role of multisectoral stakeholder leadership groups in formulating and reaching consensus on standards.