Participation in in-service training can be a challenge for health workers, especially those stationed in remote areas. Spaced education is an innovative learning methodology that can be delivered electronically by Internet or mobile smartphone. CapacityPlus conducted a pilot study that followed a convenience sample of 37 Ethiopian nationals enrolled in a spaced education course over a six-month period to determine the acceptability and effectiveness of the methodology in a low-resource context. The course content was codeveloped by Ethiopian and international nutrition experts and focused on the recently revised Ethiopian Federal Ministry of Health guidelines on the feeding of infants of HIV-positive mothers. The study suggests that the Internet-based spaced education methodology is acceptable and effective for the acquisition of knowledge in a low-resource context for course participants with a clinical or public health background and moderately reliable Internet access. More research is needed to test the feasibility, acceptability, and effectiveness of the methodology among a wider population of health workers in developing countries, and particularly among government and volunteer health workers in rural and remote settings.